BiotinPicolylAzideisanadvancedClickchemistrybiotinprobethatincorporatesacopper-chelatingmotiftoraisetheeffectiveconcentrationofCu(I)atthereactionsite.Thechelatingeffectofpicolylazidemoietytoraisetheeffectiveconcentrationofcopperatthereactionsiteissogreatthatitleadstoanincreaseofsignalintensityofupto40-fold.
Inaddition,theuseofBiotinPicolylAzideinsteadofconventionalBiotinAzideallowsforatleastatenfoldreductionintheconcentrationofthecoppercatalystwithoutsacrificingtheefficiencyoflabeling.
Insummary,theintroductionofapicolylmoietyintoanazideprobeleadstoasubstantialincreaseinthesensitivityofalkynedetection.Thiswillbeofspecialvalueforthedetectionoflowabundancetargetsorwhereseveralincreaseofsignalintensityisdesired.
Learnmoreaboutpicolylazidereagents.
| Molecularweight | 622.74 |
| Chemicalcomposition | C27H42N8O7S |
| CAS | N/A |
| Solubility | DMSO,DMF |
| Purity | >95%(HPLC) |
| Appearance | Off-whitetoslightlyorangeamorphoussolid |
| Storageconditions | -20C |
| Shippingconditions | Ambienttemperature |
